SYNTHESIS OF 3,5-DISUBSTITUTED-2,6-DIARYLPIPERIDIN-4-ONE HYDROCHLORIDES

Authors: B.Veeraswamy*, J.Jayabharathi, Mandava V. Basaveswara Rao and E.Srinivasa Reddy

Department of Chemistry, GITAM University, Visakhapatnam-530045, India;Email: Chinna341@gmail.com

A simple and efficient condensation reaction between aliphatic carbonyl compounds having active methylene protons with aromatic aldehydes and ammonium acetate yielded the corresponding 3-alkyl or 3,5-dialkyl-2,6-diarylpiperidin-4-one, which on treatment with  hydroxylamine hydrochloride yielded the corresponding oximes. All the reactions are quantitative, involves very cheap chemicals and smooth reaction conditions. So we are reporting very simple synthetic methodology for the synthesis of 3,5-disubstituted-2,6-diarylpiperidin-4-ones and their corresponding oximes.

Keywords : 3,5-disubstituted-2,6-diarylpiperidin-4-ones, 3,5-dicarboxyethyl-2,6-dimethyl-4-(2-furyl)-1,4-dihydropyridine.