| RASĀYAN - Journal Of Chemistry | Vol.2, No.1, 1-256 (2009) |
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) STUDIES OF QUINOLONE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS
Authors: K. Satya Parameshwar1, B. Ashok Kumar2, A.Siva Reddy2 andT. Parthasarathy2*
1Academic Cell, A.P. State Council of Higher Education, Hyderabad;2Molecular modeling group, Computational Chemistry Lab, Dept. of Chemistry,Nizam College , Osmania University, Hyderabad – 500 001, INDIA;E-mail: siva.reddy476@gmail.com
The antibacterial activities (IC50 ) of Quinolone derivatives against Staphylococcus aureus were quantitatively analyzed in terms of physicochemical parameters by regression analysis and a model quantitative structure activity relationship (QSAR) is obtained. The predictive potential of the model is discussed on the basis of lipophilicity parameter, QlogP and electronic parameter, σ. An increase in QlogP and σ has a negative influence on the activity. The best pharmacophore would be a compound with least QlogP and σ values.
| Page No. : 247-250 | Received:22 February 2009 Accepted: 1 March 2009 RJC-336 |
