SYNTHESIS OF NOVEL THIAZOLO-QUINAZOLINES AS ANTINOCICEPTIVE AND ANTI-INFLAMMATORY AGENTS

Authors: T.Panneer Selvam*, C.R.Prakash 1, G.Saravanan2, V.Karthick and P.Dinesh Kumar

*1Department of Pharmaceutical Chemistry, D.C.R.M. Charmacy College, Inkollu(A.P), India; 2Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla(A.P), India; E-mail: tpsphc@gmail.com

A series of 6,7,8,9 tetra hydro-5H-5-(2'-hydroxy phenyl)-2-(4'-some substituted benzylidine) thiazolo (2,3-b) quinazolin-3(2H)-one (4a-4d) and 6,7,8,9 tetra hydro-5H-5-(2'-hydroxy phenyl)-2-(4'-some substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline (5a-5d ) have been synthesized. All the newly synthesized compounds chemical structure were confirmed by IR, ¹H-NMR, mass spectroscopy and elemental analysis. The new compounds have been tested for their antinociceptive, anti-inflammatory activities. The results of studies indicate that the hydroxy substitution in the benzylidine ring increased the anti-inflammatory and antinociceptive activities.

Keywords : Thiazolo quinazoline; Antinociceptive activity; Anti-inflammatory.