| RASĀYAN - Journal Of Chemistry | Vol.3, No.1, 1-200 (2010) |
SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF LEUKOTRIENE RECEPTOR ANTAGONIST IN BULK DOSAGE FORMS
Authors: J.V. Shanmukha kumar1*, D. Ramachandran2, V.S. Settaluri 3 and C. Shechinah Felice 3
1Department of Chemistry, College of Engineering, K L E F University, Vaddeswaram-522502, Guntur, A.P, India; 2Department of Chemistry, Acharya Nagarjuna University, Nuzvid Campus,Nuzvid, Krishna District, A.P, India; 3Department of Biotechnology, College of Engineering, K L E F University,Vaddeswaram – 522 502, Guntur, A.P, India; *E-mail: shanmuk_fed@klce.ac.in
Three simple, accurate and economical spectroscopic methods were developed for the determination of Montelukast Sodium in bulk and dosage forms. Method A is based on the reduction of ferric ion into ferrous ion by the drug (MTK) in the presence of a ligand 1, 10-phenanthroline to form a highly stable orange red colored complex having lmax at 510 nm with a molar absorptivity of 1.652 x 104. Method B for montelukast sodium is based on the oxidation of Fe (III) followed by coupling with MBTH, to form a highly stable green colored chromogen having lmax at 610 nm with a molar absorptivity of 0.7176 x104. Method C is based on reaction of the drug (MTK) in the presence of the ligand 2, 2’-Bipyridyl to form a highly stable orange colored chromogen having lmax at 430 nm with a molar absorptivity of 1.672 x104. Common excipients involved in routine pharmaceutical preparations do not interfere in any of the proposed methods. The results of analysis have been validated statistically and recovery studies confirm the accuracy of the proposed methods.
| Page No. : 166-171 | Received: 4 March 2010 Accepted: 13 March 2010 RJC-529 |
