| RASĀYAN - Journal Of Chemistry | Vol.1, No.1, 1-197 (2008) |
ANTIBACTERIAL ACTIVITY OF SOME N,N'-LINKED BISAZAHETEROCYCLES, BENZIMIDAZOLINE AND QUINOXALINE DERIVATIVES
Authors: G. Mahesh Reddy* and P. S. N. Reddy
Department of Chemistry, Osmania University, Hyderabad-500 007, India;*$Present Address for communication: Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO COMPANY), 28A, IDA, Nacharam, Hyderabad-500 076, India;E-mail: reddyghanta@yahoo.com
Seventeen derivatives of quinazolinonyl-pyrrolidinones/quinazolinediones/ benzodiazepindiones, bisquinazolinones, bisbenzodiazepinones, benzimidazoline and quinoxalines, earlier synthesized by us, are screened for antibacterial activity against Staphylococcus aureus MTCC96 and Escherichia coli MTCC119 by paper disc diffusion method using streptomycin as control. Compound 8 was the most active and equipotent with that of the control at 6.25 mg/disc concentration. Compounds 5, 8, 12, 13a and 13c exhibited high antibacterial activity against Escherichia coli MTCC119.
| Page No. : 179-184 | (Received: 3 October 2007 Accepted: 12 January 2008 RJC-122) |
