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| RASĀYAN - Journal Of Chemistry | Volume 3, Number 2, 201-384, April-June(2010) |
SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF CHLORO-SUBSTITUTED-1, 3-THIAZINES
Authors: S. P. Rathod1*, A. P. Charjan1 and P. R. Rajput2
1Department of Chemistry, G. S. G. College, Umarkhed (MS) India; 2Department of Chemistry, Vidyabharti Mahavidyalaya, Camp Amravati; *E-mail:rathod_suresh2009@rediffmail.com
The synthesis, spectral analysis and biological activities of some 4-phenyl-2-hydroxy-chlorosubstituted-2-imino-1, 3-thiazene with phenyl thiourea and diphenyl thiourea have been carried out in two series. In series I we got 4-(2-hydroxy-3,5-dichlorophenyl-6-(ethyl)-2-iminophenyl-1,3-thiazene and 4-(2-hydroxy-3,5-dichlorophenyl-6-(ethyl)-2-iminophenyl-3-phenyl-1,3-thiazene(3a-6a) from 2-hydroxy-3,5-dichloroacetophenone from phenyl thiourea and in series II 4-(2-hydroxy-3,5-dichlorophenyl)-6-(hexyl)-2-iminophenyl-1,3-thiazene and 4-(2-hydroxy-3,5-dichlorophenyl)-6-(hexyl)-2-iminophenyl-3-phenyl-1,3-thiazene(3b-6b) were synthesized from diphenyl thiourea. All these compounds have been analyzed by UV, IR and NMR for structure assignment. The Antibacterial activities of these compounds were studied.
| Page No. : 363-367 | (Received: 27 May 2010 Accepted: 24 June 2010 RJC-565) |
