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| RASĀYAN - Journal Of Chemistry | Vol.3, No.4, 615-824, Oct.-Dec., 2010 |
QUANTITATIVE ANALYSIS OF MEPHEDRONE IN BULK AND PHARMACEUTICAL FORMULATIONS BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: C.Rambabu1,* S.Venkata Rao1, G.Ramu1 and A.Biksham Babu1
*E-mail: rbchintal@gmail.com
A rapid, precise, economical and accurate reverse phase liquid chromatographic method for estimation of Mephedrone in bulk and formulations was developed and validated. The Chromatographic resolution of Mephedrone was achieved using Acetonitrile: 0.1M Ammonium Acetate Buffer PH~ 4, (40: 60 V/V) as a mobile phase UV detection at 232 nm and C18 column .flow rate 1ml/min. Recovery of Mephedrone from its formulation dosage form was greater than 99.8% . Calibration curve was linear (r2 = 0.9992) over Mephedrone concentration ranging From 20 to 120 μ g /ml. the method has an accuracy of greater than 99% . The LOD and LOQ of the drug were 0.80339 μ g /ml and 2.43450 μ g /ml respectively. Results were validated statistically and recovery studies were found to be satisfactory.
| Page No. : 796-799 | RJC-691/2010 |
