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| RASĀYAN - Journal Of Chemistry | RJC, Vol.4, No.3, 498-700(2011) |
REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF SATRANIDAZOLE IN PHARMACEUTICAL FORMULATIONS
Authors: K. Kiran Kumar1 and R. Venkata Nadh2
*E- mail: kiran_79@ymail.com
A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the determination of satranidazole in pharmaceutical formulations. The method was carried out on a isocratic ODS - C18 (250 x 4.6mm i.d.,5 μ) column with a mobile phase consisting of Acetonitrile , 0.025M Ammonium phosphate buffer and 1.0% Ortho phosphoric acid in the ratio 65:35:5 v/v/v) at a flow rate 1.2mL/min. Detection was carried out at 318nm using UV lamp visible detector. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for the estimation of satranidazole in pharmaceutical formulations.
| Page No. : 681-685 | RJC-778/2011 |
