DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF ETORICOXIB IN BULK AND TABLET FORMULATION

Authors: S.R. Shahi*, G.R. Agrawal, P.B. Rathi, N.V. Shinde, V.G. Somani , S.B. Mahamuni and A.N. Padalkar

* Government College of Pharmacy, Vedant Road, Aurangabad, M.S.-431005.;E-mail: sadhanashahi@yahoo.com

All immediate release tablets are subjected to dissolution studies in 0.1 N HCl as recommended by SUPAC-IR guidelines or in specified dissolution medium as per their official monograph. The present UV spectrophotometric method is simple, accurate, specific and highly sensitive, developed in 0.1 N HCL and very useful for analysis of immediate release tablets. The method is    validated for the determination of Etoricoxib in bulk and tablet dosage form. Etoricoxib is the newest addition to the group of Non-Steroidal Anti-Inflammatory Drugs - highly selective COX-2 inhibitor. The standard solution of etoricoxib in 0.1N HCl showed maximum absorption at 233 nm. Beer-Lambert’s law obeyed in the concentration range of 2-24 µg/ml, with regression, slope and intercept 0.9996, 0.072 and 0.089 respectively. The percentage recovery is 99.965 which reflect that the method is free from interference of the impurities and other additives during the estimation of drug in formulation. The proposed method can be successfully used for analysis of etoricoxib in marketed preparations. The results of analysis have been validated statistically and by recovery studies.

Keywords : Etoricoxib, UV determination, Tablet dosage form, SUPAC guidelines.